Psychiatry: Archives

SUMMARY AND COMMENT

Of Depressed Mice and Men: Similar Genetic Expression in the Amygdala

• August 10, 2009
• Joel Yager, MD

An elegant cross-species study homes in on genetic expression in depression. CME

• Reviewing:
• Sibille E et al., Am J Psychiatry 2009 Jul 15

SUMMARY AND COMMENT

A Polygenic Basis for Major Disorders?

• August 10, 2009
• Barbara Geller, MD

Common polymorphisms that individually exert small effects might, as a group, play a substantial genetic role.

• Reviewing:
• Purcell SM et al. for the International Schizophrenia Consortium., Nature 2009 Jul 1 Shi J et al., Nature 2009 Jul 1 Stefansson H et al., Nature 2009 Jul 1

SUMMARY AND COMMENT

Delaying Progression to Alzheimer Disease

• August 10, 2009
• Jonathan Silver, MD

Donepezil might work, if the patient with amnestic mild cognitive impairment is (a little) depressed.

• Reviewing:
• Lu PH et al., Neurology 2009 Jun 16; 72:2115

SUMMARY AND COMMENT

ECT: Alone or with Medication?

• August 10, 2009
• Steven Dubovsky, MD

Some insights into a long-standing question CME

• Reviewing:
• Sackeim HA et al., Arch Gen Psychiatry 2009 Jul; 66:729

SUMMARY AND COMMENT

Schizophrenia and Bipolar Disorder Run in the Same Families

• August 10, 2009
• Steven Dubovsky, MD

A meta-analysis of familial coaggregation studies yields positive results.

• Reviewing:
• Van Snellenberg JX and de Candia T., Arch Gen Psychiatry 2009 Jul; 66:748

SUMMARY AND COMMENT

Using Biomarkers to Predict Alzheimer Disease: Not Yet Ready for the Clinic

• August 10, 2009
• Peter Roy-Byrne, MD

An assay of several spinal-fluid proteins to diagnose AD is promising but unlikely to be immediately adopted because of testing differences between centers.

• Reviewing:
• Mattsson N et al., JAMA 2009 Jul 22/29; 302:385

SUMMARY AND COMMENT

Who Overuses Headache Medications? An Easy Method of Detection

• August 3, 2009
• Jonathan Silver, MD

A five-item questionnaire can help clinicians to diagnose this common problem.

• Reviewing:
• Grande RB et al., J Neurol Neurosurg Psychiatry 2009 Jul; 80:784 Lucas C and Diener H-C., J Neurol Neurosurg Psychiatry 2009 Jul; 80:704

SUMMARY AND COMMENT

Which Psychotherapy Works for Patients with Generalized Anxiety Disorder?

• August 3, 2009
• Joel Yager, MD

Both CBT and short-term psychodynamic psychotherapy were effective in a group of relatively healthy patients. CME

• Reviewing:
• Leichsenring F et al., Am J Psychiatry 2009 Jul 1

SUMMARY AND COMMENT

Should Clozapine Be a First-Line Treatment for Schizophrenia?

• August 3, 2009
• Peter Roy-Byrne, MD

Despite its cardiometabolic risks, the drug reduced the risk for death.

• Reviewing:
• Tiihonen J et al., Lancet 2009 Jul 11

SUMMARY AND COMMENT

Factors in Middle Age Might Predict Later Dementia

• August 3, 2009
• Joel Yager, MD

Being calm and staying married may reduce the risks for dementia.

• Reviewing:
• Gallacher J et al., Psychosom Med 2009 Jul; 71:659 Håkansson K et al., BMJ 2009 Jul 2; 339:b2462